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Dr. Daniel Falush
Senior Research Fellow
Research interests :
I obtained my bachelor degree in Mathematics at the University of Cambridge and a PhD in Genetics at University College London. Postdoctoral work in statistical genetics at Kyushu University Japan and the Max Planck Institute for Infection biology in Berlin. Was a research fellow first in the University of Oxford (funded by the Wellcome Trust 2003-2008). My research involves developing statistical methodology for analysing genetic data (for example the programs STRUCTURE and ClonalFrame) and using the methods to elucidate organismal biology. I work mostly on bacteria but have been involved in a variety of side-projects in humans and other organisms. Major current projects include the successor to ClonalFrame (with Dan Lawson, Xavier Didelot and Aaron Darling) and methods for defining human ancestry based on genome-wide SNP data (with Garrett Hellenthal and Simon Myers).
Key Publications
- Hellenthal G, Auton A, Falush D. Inferring human colonization history using a copying model.
PLoS Genetics 2008 4 e1000078
- Sheppard SK, McCarthy ND, Falush D, Maiden MCJ. Convergence of Campylobacter species: implications for bacterial evolution.
Science 2008 320 237-239.
- Didelot X, Falush D. Inference of bacterial microevolution using multilocus sequence data.
Genetics 2007 175 1251-1266.
- McCarthy ND, Colles FM, Dingle KE, Bagnall MC, Manning G, Maiden MCJ, Falush D. Host associated genetic import in Campylobacter jejuni.
Emerging Infectious Diseases 2007 13 267-272;
- Didelot X, Acthman M, Parkhill J, Thomson N, Falush D. A bimodal pattern of relatedness between Salmonella Typhi and Paratyphi A: convergence or divergence by homologous recombination?
Genome Research 2007 17 61-68.
- Falush D, Torpdahl M, Didelot X, Wilson DJ, Conrad D, Achtman M. Mismatch induced speciation in Salmonella: model and data
Philosophical Transactions of the Royal Society B 2006 361 2045-2053.
- Falush D, Stephens M JK Pritchard. Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies.
Genetics 2003 164 1567-1587.
- Falush D, Wirth T, Linz B, Pritchard JK, Stephens M, Kidd M, Blaser MJ, Graham DY, Vacher S, Perez-Perez GI, Yamaoka Y, Megraud F, Otto K, Reichard U, Katzowitsch E, Wang X, Achtman M, Suerbaum S. Traces of human migrations in Helicobacter pylori populations.
Science 2003 299 1582-1585.
- Falush D, Kraft C, Taylor NS, Correa P, Fox JG, Achtman M, Suerbaum S. Recombination and mutation during long-term gastric colonization by Helicobacter pylori: Estimates of clock rates, recombination size and minimal age.
PNAS 2001 98 15056-15061.
- Falush D, Almqvist EW, Brinkman RR, Iwasa Y, Hayden MR. Measurement of mutational flow implies both a high new mutation rate for Huntington Disease and substantial under-ascertainment of late onset cases.
American Journal of Human Genetics 2001 68 373-385.
Contact details:
Tel: + 353 21 490 1981
e.mail: d.falush@ucc.ie
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